产品货号：
GS4577
中文名称：
重组大鼠IL-33
英文名称：
Recombinant Rat Interleukin 33
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 17.4kDa,a single non-glycosylated polypeptide chain containing 156 amino acids.
储存条件：冷冻（-20℃）
概述
Interleukin-33(IL-33),also known as NF-HEV and DVS 27,is a cytokine belonging to the IL-1 superfamily.It is also a proinflammatory protein that may regulate gene transcription and it induces helper T cells,mast cells,eosinophils and basophils to produce type 2 cytokines.The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.IL-33 is constitutively expressed in smooth muscle and airway epithelia and it binds to a high-affinity receptor family member ST2.In vivo administration of mature IL-33 promotes increased production of IL-5,IL-13,IgE,and IgA,as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59%a.a.and 90%sequence identity with human and murine IL-33.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组大鼠IL-33，IL-33, Rat，Recombinant Rat Interleukin 33
储存条件：冷冻（-20℃）
概述
Interleukin-33(IL-33),also known as NF-HEV and DVS 27,is a cytokine belonging to the IL-1 superfamily.It is also a proinflammatory protein that may regulate gene transcription and it induces helper T cells,mast cells,eosinophils and basophils to produce type 2 cytokines.The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.IL-33 is constitutively expressed in smooth muscle and airway epithelia and it binds to a high-affinity receptor family member ST2.In vivo administration of mature IL-33 promotes increased production of IL-5,IL-13,IgE,and IgA,as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59%a.a.and 90%sequence identity with human and murine IL-33.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5ng/ml,corresponding to a specific activity of>2.0×106 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris,300 mM NaCl,pH 8.5. |
| 内毒素 | Less than 1 EU/μg of rRtIL-33 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | SIQGTSLLTE SCALSTYNDQ SVSFVLENGC YVINVEDCGK NQEKDKVLLR YYESSFPAQS GDGVDGKKLM VNMSPIKDTD IWLNANDKDY SVELQKGDVS PPDQAFFVLH KKSSDFVSFE CKNLPGTYIG VKDNQLALVE ENDESCNNIM FKLSKM |
相关搜索：重组大鼠IL-33，IL-33, Rat，Recombinant Rat Interleukin 33